Lee YY, Van Tassel P, Nauert C, North LB, Jing BS. Diagn Cytopathol. https://doi.org/10.1038/modpathol.2016.152. Connect with a U.S. board-certified doctor by text or video anytime, anywhere. Vose JM. Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status. As seen in Figure 1, the soft palate, uvula, and posterior pharynx demonstrate multiple areas of enlargement that are consistent with lymphoid tissue. Cytoplasmic composition also varied between cases, from abundant to scant. By using this website, you agree to our 1, pp. The outer cortex is composed of follicles of B cells so that it is called the B-cell zone. The pathological diagnosis was MCL. b. H&E showed immunoblastic large cells with an obvious nucleolus (200 x). During the follow up period, the MCL patient and an elderly DLBCL patient died. https://doi.org/10.1016/j.ijom.2004.08.009. Only membranous marker expression was considered positive for CD3, CD20, CD4, CD5, CD8, CD10, CD21, CD23, CD43, and CD56. This may be because the case occurred before drugs such as rituximab were widely available. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. What are chaces of malignancy?What precautions for future shud i take? These lymphoid tissues are controlled by specialized cells that arm themselves to attack and destroy foreign invaderssuch as bacteria, fungi, or virusesthrough phagocytosis or the production of antibodies. These cells are designed to fight. On this Wikipedia the language links are at the top of the page across from the article title. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. All 7 lymphomas were localized at the base of the tongue. This is because reactive growth of lymphoid tissue can be difficult to distinguish from the most serious neoplastic lesions.1. Patricia Uherova et al. 2011;24:98392. In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. Three patients are alive with disease and 2 are alive without disease. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot potato voice' dysphonia. 1998;112:9914. https://doi.org/10.1097/01.dad.0000246949.49071.17. Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. Jain KS, Sikora AG, Baxi SS, Morris LG. e. HPV DNA ISH showed brown punctate dots in the tumour cell nucleus or cytoplasm (400x).f. While the etiology is poorly understood, a number of previous theories exist, which are included here in the context of a literature review. Three patients were at an early stage (stage I and II) and had low IPI scores (0 or 1). EBV ISH was performed using EBV-encoded Small RNA (EBER) probes (Bond ready-to-use ISH, Catalogue No: PB0589, Leica Biosystems Newcastle, Ltd.) according to the manufacturers protocol. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. Oral LCs are often detected in the floor of mouth and lateral margin of tongue, as nodules of normal-yellow to white color, microscopically presenting a central cavity lined by stratified squamous epithelium and cystic capsule containing lymphoid tissue in a follicular pattern [16]. Among our cases, there were 1 GC and 3 NGC cases. We conclude that the frequency of hypertrophied follicles is increased in the presence of signs and symptoms of GER and those HBT symptoms are confused with those of GER, except for nasal voice and noisy respiration. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. a. CT showed a well-bordered cystic mass. Primary extra-nodal non-Hodgkin's lymphoma of the cheek. Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K, Nakamura S. Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. The clinical stage was IV A. Acta Oncol. The DLBCL, NOS cases were further divided into GC and NGC B cell like subtypes based on immunohistochemical expression of CD10, Bcl-6 and Mum1 [11]. Uherova P, Ross CW, Finn WG, Singleton TP, Kansal R, Schnitzer B. CAS The role of EBV in the pathogenesis of diffuse large B cell lymphoma. 4 Metrics Downloaded 279 times PDF download Imaging and pathological findings of MCL (case 2). XS and QL did the HPV ISH. d. Tumour cells were positive for CD5 (200x). Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. Narla S, Annapurneswari S, Parameswaran A, Nair S. Peripheral T-cell lymphoma of tongue: Report of a rare case and review of literature. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. HHS Vulnerability Disclosure, Help https://doi.org/10.1200/JCO.2005.07.155. 2017;30:S4453. Clinical images of entities may be beneficial for documentation purposes, as they may be viewed during future appointments should there be recurrences. The lingual tonsil is located at the base of the tongue and related to circumvallate papillae, whereas subepithelial lymphoid tissue at the posterior lateral portion of the tongue and related to foliate papillae constitutes the lateral lingual tonsil. Ekstrom-Smedby K. Epidemiology and etiology of non-Hodgkin lymphoma--a review. The therapeutic response is related to the pathological subtype and several factors, such as old age, high grade histology, bulky lymph nodes, higher IPI score, and advanced stage [22, 24, 25]. https://doi.org/10.1038/modpathol.3880541. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. All cases were reviewed and diagnoses were confirmed based on basic morphology, immunohistochemistry staining, and rearrangement. https://doi.org/10.1053/ajot.2000.8382. Blood. There were no c-Myc rearrangements, so there were no double or triple hit B cell lymphomas in these cases (Table3). Accessibility The .gov means its official. It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. The surface of the tongue in this area is made up primarily of lymphoid tissue known as the lingual tonsil. In our case, the late stage of disease, the morphologically blastic variant [44], and involvement of neck lymph nodes were all factors that contributed to poor prognosis of this patient. Asian Pac J Cancer Prev. For these, please consult a doctor (virtually or in person). Would you like email updates of new search results? 2014;3:731. https://doi.org/10.1186/2193-1801-3-731. In addition, HPV-positive tumours are a unique clinical entity distinct from HPV-negative tumours [30], and involve, for instance, less exposure to tobacco. Samples were assayed using a BOND HPV probe set specific to HPV subtypes 16, 18, 31, 33 and 51 (Bond Ready-to-Use ISH HPV Probe, CAT # PB0829) on the Leica BOND-MAX system. The same study also showed that lymphoma at this site is always early stage [21, 24]. https://doi.org/10.1007/978-3-319-22822-8_13. The prognosis for MCL seems to be poorer than that for DLBCL at the base of the tongue. PubMed https://doi.org/10.1159/000278291. It tends to present as a unilateral, painless, slow-growing, nonulcerated mass. LH most commonly affects older patients, with a mean age of 61 and female-to-male ratio of nearly 3:1. This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. f. Tumour cells were negative for CD5 (200 x). Sinus hyperplasia may be associated with non-hematolymphoid malignancy. 3840, 1973. One of the DLBCL cases was positive for HPV DNA and diffusely expressed P16 protein. c. Tumour cell infiltrated squamous epithelium (400x). Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. In the literature, findings of RLH are well-documented. 1987;149:57581. Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. Is it always necessary to carry out a biopsy on lymphoid hyperplasia or is endoscopic examination and MRI enough to decide that it is benign? 4, pp. [citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. https://doi.org/10.1016/j.ijom.2010.03.029. https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. Except in one case, all patients exhibited a tongue base mass with smooth and intact membrane surface. Chang CC, Liu YC, Cleveland RP, Perkins SL. Paracortical hyperplasia may be accompanied by vascular proliferation. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. In terms of pathological characteristics, 6 patients were diagnosed with B-cell NHL, and 1 patient was diagnosed with PTCL, NOS (Table2). 2023 BioMed Central Ltd unless otherwise stated. Lymphoma cases were selected from 2010 to 2017 in PUMCH, and all cases were reviewed to identify lymphomas arising from the base of the tongue instead of other primary sites. These tissues act as your body's first line of defense against infections. Not applicable. Two patients, including our patient, died during follow-up. Oral Surg Oral Med Oral Pathol Oral Radiol. MCL usually express CD5 and CyclinD1 protein. Lailatul et al. Google Scholar. Careers. Lopez-Guillermo et al. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. 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