Serious side effects are also possible, such as infusion reactions, allergic reactions, and kidney injury. Copyright 2023 IBM Watson Health. Like all medicines, remdesivir can cause side effects in some people, although not everyone gets them. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Gilead Sciences. Visit Yellow Card for further information. Important information about using Veklury to treat COVID-19 for its approved use is available in the prescribing information which includes dosing instructions, potential side effects and drug interactions.2 Possible side effects include increased levels of liver enzymes, which may be a sign of liver injury; and allergic reactions, which may include changes in blood pressure and heart rate, low blood oxygen level, fever, shortness of breath, wheezing, swelling (e.g., lips, around eyes, under the skin), rash, nausea, sweating or shivering. The BMJ article implies that the story of remdesivir is another scandal waiting to happen. As a consequence of being mostly ineffective, WHO recommends against the use of remdesivir in Covid-19 patients. Ritonavir may reduce the efficacy of combined hormonal contraceptives. Beneficial with conventional oxygen therapy. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Side Effects of Remdesivir Include Possible Liver Damage & Nausea Getty A doctor and nurses wear protective, suits, masks, goggles, and gloves as they perform the morning medical checks inside. Itll depend on your body weight, symptoms, and other health conditions you may have. There are things you can do to help cope with them: Headache Feeling sick or being sick (nausea or vomiting) Serious side effects Tell your doctor or contact 111 now if you feel that your heart is beating slower than normal. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. A 2020 study of over 1,000 people hospitalized with the disease found that it safely and effectively shortened the time to recovery in adults. However, its not always clear if this effect on liver enzymes is due to remdesivir, COVID-19 itself, or both. You may be asked to take blood tests before being treated with remdesivir and while you're having the treatment. "The benefit to patients with intensive ventilation support remains unclear," explains Dr. Alain Amstutz, first author of the study. Doctors may consider adjusting doses of certain antibiotics before prescribing them to people with renal failure. Remdesivir API is complex and neither a United States Pharmacopeia (USP) monograph nor other public quality standard for the API used in FDA-approved remdesivir is available. (2022). U.S. Food and Drug Administration. In rare cases, it can cause allergic reactions. Another plus: Remdesivir has fewer drug interactions than Paxlovid. It has remained disputed how well the medication works and whether it benefits some patient groups more than others. On the other hand, remdesivir can increase field potential duration with decreased Na + peak amplitudes and . This hypothetically raises your risk for bleeding-related complications. Find information on Remdesivir (Veklury) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Will Future Computers Run On Human Brain Cells? Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on pathogenic animal and human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, and inhibits Middle East respiratory syndrome coronavirus, SARS-CoV-1, and SARS-CoV-2 replication in animal models. Check the pill packet to find out what to do. Make sure you tell your doctor if you have any other medical problems, especially: Kidney diseaseUse with caution. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution in patients receiving remdesivir injection. (2021). A recent case report reported improvement of clinical symptoms with remdesivir in a patient with COVID-19. Dexamethasone can cause several potential side effects . This is to check if you have early signs of side effects. Youve heard about its ability to spread easily, the complications it can cause, and how viral variants are making preventing and treating it all the more complex. If we combine this information with your protected
FDA approved a new drug application (NDA) for Veklury (remdesivir), a drug indicated for adults and pediatric patients (12 years of age and older and weighing at least 40 kg) for the treatment of COVID-19 requiring hospitalization on October 22, 2020.1 The Veklury approval includes two presentations: remdesivir for injection, 100 milligrams (mg), a sterile, preservative-free lyophilized powder and remdesivir injection, 100 mg/20 milliliters (mL) (5 mg/mL), a sterile, preservative-free solution. University of Basel. Galactic Explosion: New Insight Into the Cosmos, New Superacid Discovered: Special Catalyst, See Hidden Objects With Augmented Reality, Tiny New Climbing Robot Inspired by Inchworms, Dinosaur Claws Used for Digging and Display, Support from Others in Stressful Times Can Ease Impact of Genetic Depression Risk, Study Suggests, Gut Microbes Can Boost the Motivation to Exercise, This Groundbreaking Biomaterial Heals Tissues from the Inside out, Holding Information in Mind May Mean Storing It Among Synapses, Supplementation With Amino Acid Serine Eases Neuropathy in Diabetic Mice, Humans and Nature: The Distance Is Growing, Why Chocolate Feels So Good -- It Is All Down to Lubrication, Coffee With Milk May Have an Anti-Inflammatory Effect, Reducing Total Calories May Be More Effective for Weight Loss Than Intermittent Fasting, Tiny New Climbing Robot Was Inspired by Geckos and Inchworms, Custom, 3D-Printed Heart Replicas Look and Pump Just Like the Real Thing, First Transient Electronic Bandage Speeds Healing by 30%. A propensity scorematched observational study of remdesivir in patients with COVID-19 and severe kidney disease. Electrodes Grown in the Brain -- Paving the Way for Future Therapies for Neurological Disorders, Wireless, Soft E-Skin for Interactive Touch Communication in the Virtual World, Want Healthy Valentine Chocolates? Remdesivir, steroids are spiking blood sugar levels, . Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site Other side effects not listed may also occur in some patients. Remdesivir is an antiviral drug.In the United States, remdesivir may also be used to treat patients with COVID-19 who are not in the hospital, but have a high risk for COVID-19 complications. I would also like to sign up for a free GoodRx account. Retrieved from, European Medicines Agency. Remdesivir. Side effects from remdesivir can include nausea, vomiting, chills and elevated liver enzymes, which could potentially cause liver damage. Remdesivir is used with caution in people with certain kidney problems. Speak to your doctor if this does not help or your headaches are severe. GoodRx works to make its website accessible to all, including those with disabilities. Remdesivir may cause several side effects. Tamiflu only cost $75 per treatment and yet was still a massive waste of money. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. It slows down an enzyme (protein) that the virus needs in order to make copies of itself. In addition to complexities and risks related to the API, remdesivir drug products are complex to produce. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Angioedema. https://www.nejm.org/doi/full/10.1056/nejmoa2007764, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907730/, https://pubmed.ncbi.nlm.nih.gov/33340409/, https://jasn.asnjournals.org/content/32/2/518, https://bmjopen.bmj.com/content/12/3/e048502, https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/remdesivir/, https://medlineplus.gov/druginfo/meds/a620033.html, https://www.frontiersin.org/articles/10.3389/fphar.2022.692828/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446775/, Skipping breakfast and fasting may compromise the immune system. Date November 8, 2021 Most of us are familiar with COVID-19's hallmark symptoms of a loss of taste or smell and difficulty breathing, but a full 60 percent of patients infected with SARS-CoV-2 also report gastrointestinal symptoms such as nausea, diarrhea, and stomach pain. the unsubscribe link in the e-mail. Remdesivir is an experimental drug developed by biotech company Gilead Sciences (under the brand name Veklury) in collaboration with the US Centers for Disease Control and Army Medical Research Institute of Infectious Diseases. Remdesivir is generally well-tolerated. We Can Print Them, Human-Approved Medication Brings Back 'Lost' Memories in Mice, See No Evil: People Find Good in Villains, Interferon Does Not Improve Outcomes for Hospitalized Adults With COVID-19, Clinical Trial Finds, Rethinking Remdesivir: Researchers Modify Current Drug, Creating Oral Version That Can Be Taken Earlier in COVID-19 Diagnoses, Hepatitis C Drugs Combined With Remdesivir Show Strong Effectiveness Against COVID-19, Study Finds, Experts Make Weak Recommendation for Remdesivir in Severe COVID-19, CCPA/CPRA: Do Not Sell or Share My Information. Dizziness. Bland meat taste best. This content does not have an Arabic version. Given these risks, FDA is concerned about the potential for patient exposure to substandard or adulterated compounded remdesivir drug products. Coronaviruses have genomes made up ribonucleic acid (RNA). StatPearls. Liver diseaseUse with caution. Typical kidneys can remove SBECD from the body. The data covers over 10,000 unvaccinated patients from over 40 countries who were treated for COVID-19 in a hospital. Low blood pressure. The goal was to find out which patient groups, if any, benefited from remdesivir. In studies, the most common side effects have included: A person may also experience pain, bleeding, or bruising at the injection site. Individuals should speak with a doctor or nurse immediately if they experience the following symptoms during or after their remdesivir infusion: Doctors may stop or adjust a persons treatment if they experience any of these side effects. It is also used to treat mild to moderate COVID-19 in non-hospitalized patients who are at high risk for progression to severe COVID-19 (eg, hospitalization, death). If youre experiencing nausea or other side effects that are annoying or intolerable, make sure to talk to your healthcare provider. The presence of other medical problems may affect the use of this medicine. include protected health information. Although not all of these side effects may occur, if they do occur they may need medical attention. It's best not to drink too much alcohol. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. of remdesivir in human milk, the effects on the breastfed infant, or the effects on milk production. In the hospital, a person takes remdesivir intravenously through a vein, in a procedure that takes 30120 minutes. Remdesivir has potential side-effects on the kidneys, according to data shared by Gilead with the European Medicines Agency, which is assessing its possible toxicity. Possible side effects include increased levels of liver enzymes, which may be a sign of liver injury; and allergic reactions, which may include changes in blood pressure and heart rate, low blood . The effects may be increased because of slower removal of the medicine from the body. Remdesivir is an antiviral medication that targets the RNA in viruses to prevent replication. Foods that are beneficial for kidney health include dark leafy greens, berries, and apples. If youre experiencing a common side effect like nausea, you can try a few different things to control your symptoms. These side effects may go away during treatment as your body adjusts to the medicine. Side effects: They're usually mild, and may include altered or impaired sense of taste, diarrhea, increased blood pressure, or muscle aches. This could also be due to the fact that little data is available about this group. . Covid-19 vaccines have been developed 10 times faster than traditional drugs, but they've passed the phase-3 clinical trials that test whether a potential medicine is both safe and effective in thousands of people. Stay informed and get prescription saving tips and more from GoodRx Health. This medicine may cause serious allergic reactions, including infusion-related reactions and anaphylaxis, which can be life-threatening and require immediate medical attention. One of remdesivir's flaws is its (possibly toxic) high dosage over a short timeframe, which contributes to adverse side effects. A research team from the University of Basel and the University Hospital of Basel led by clinical epidemiologist Professor Matthias Briel has now collected and reanalyzed individual patient data from eight randomized clinical trials. Review/update the
Typical antiviral drug side effects include nausea and vomiting. Purple vegetables and tubers may have superior anti-diabetic properties. It's used in hospitals for more severe COVID-19, too. Digestive Diseases and Sciences. However, since remdesivir has been approved and recommended for use, weve learned more about its possible risks and side effects. (2022). Indication. When viruses like SARS-CoV-2 are no longer able to replicate inside your cells, they begin to die off. You could be having a serious allergic reaction and may need immediate treatment in hospital. In addition to whats mentioned above, rare but serious side effects are also possible. Obesity linked to 21 genes related to Alzheimers disease, study finds. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. What are the side effects? a light-headed feeling, like you might pass out; Common side effects may include: abnormal liver function tests; or. Remdesivir-induced cardiotoxicity is due to its binding to human mitochondrial RNA polymerase. Serious side effects of remdesivir "Product Information. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. The blood reports may show an increase in the levels of liver enzymes. This is not a complete list of side effects and others may occur. Tell your doctor or contact 111 now if you feel that your heart is beating slower than normal. National Human Genome Research Institute. The commonly experienced side effects are the following: - Nausea and vomiting. Because GS-441524 and remdesivir are so similar, any adverse effects uncovered in cats might have to be reported and investigated to guarantee remdesivir's safety in humans. Acute kidney injury associated with remdesivir: A comprehensive pharmacovigilance analysis of COVID-19 reports in FAERS. May make this condition worse. These side effects may go away during treatment as your body adjusts to the medicine. 2 General information about the safe and effective use of VEKLURY. Remdesivir, an anti-viral prodrug originally developed to treat Ebola virus disease, has shown broad spectrum activity against the Coronavirus family. Remdesivir's effect on the liver also disqualifies patients taking medications with known side effects to the liver. Keep in mind that not all side effects are visually noticeable. Common side effects of remdesivir may include: nausea; or abnormal liver function tests. All rights reserved. Moreover, the pH of the formulation in the approved drug is critical to ensure the stability of the formulation. A main reason is because remdesivir infusions also contain an ingredient called betadex sulfobutyl ether sodium. Remdesivir underwent several studies and showed general effectiveness in treating COVID-19. People may use the terms renal insufficiency and renal failure interchangeably. In the second new study, researchers at the University of Texas at Austin used 'cryogenic-electron microscopy' (cryo-EM) to take snapshots of the structure of the molecules involved in replication as they would interact in a Covid patient. (2021). You may report them to the FDA. It may be challenging for compounders to formulate remdesivir drug products that will remain stable over time and have an appropriate pH. Some symptoms, like nausea, may only be obvious to you. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Can diet help improve depression symptoms? Remdesivir can delay your ability to form blood clots. This risk is generally highest if youre critically sick with COVID-19. Patients should use an effective alternative contraceptive method or an additional barrier method of contraception. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). There are things you can do to help cope with them: Make sure you rest and drink plenty of fluids. [Ref], In studies in healthy subjects, increases in ALT, AST, or both in those who received this drug were grade 1 (10%) or grade 2 (4%). This is a decision you and your doctor will make. Gupte, V., et al. First, chemical engineers at the University of Chicago found that remdesivir is better at reducing virus replication than two similar antivirals, ribavirin and favilavir. Shark from Jurassic Period Highly Evolved. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Check with your doctor or nurse immediately if any of the following side effects occur while taking remdesivir: Some side effects of remdesivir may occur that usually do not need medical attention. Some found that Covid patients who received the drug recovered faster and fewer people died, but other studies showed that it didn't reduce the length of hospitalization or death rate. For the past couple years, youve heard all about the risks of COVID-19. The site is secure. However, the specific way that remdesivir impacts your kidneys is still being studied. The most common adverse events were increased hepatic enzymes, diarrhoea, rash, renal impairment and hypotension. - Difficulty breathing. . In Conversation: Is the ketogenic diet right for autoimmune conditions? The controversy surrounding remdesivir therefore revolves around whether the drug is actually an effective treatment. View remdesivir information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, monitoring requirements and important safety information. See the end of this leaflet for a complete list of ingredients in VEKLURY. It is suitable for adults and children who are 28 days or older and weigh at least 6.6 pounds, or 3 kilograms. Gilead Sciences (2020): 2. You can learn more about how we ensure our content is accurate and current by reading our. They found a significantly higher number of cases of ARF in those who received remdesivir. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to remdesivir: intravenous powder for injection, intravenous solution. Last medically reviewed on August 29, 2022. Bland and easy-to-digest food are often ideal when youre feeling nauseous. Remdesivir is an antiviral medicine that works against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ask your healthcare professional for further advice. Time to recovery in adults over 10,000 unvaccinated patients from over 40 countries who were for... In addition to whats mentioned above, rare but serious side effects are the:..., weve learned more about its possible risks and side effects in some people, although not everyone gets.... Ability to form blood clots this could also be due to remdesivir an!, academic research institutions, and other health conditions you may have superior anti-diabetic properties )! Developed to side effects of remdesivir Ebola virus disease, study finds mitochondrial RNA polymerase goal was find. Occur they may need medical attention of over 1,000 people hospitalized with the disease found that it and! Waste of money to check if you feel that your heart is beating slower than normal contraceptive... Hospitals for more severe COVID-19, too in adults medical News Today has strict guidelines! Include: abnormal liver function tests research ( MFMER ) the most adverse! # x27 ; s effect on liver enzymes is due to the medicine for severe! Arf in those who received remdesivir which can be life-threatening and require immediate medical attention effective alternative contraceptive method an... Check if you have any other medical problems may affect the use of this medicine may serious... To check if you have any other medical problems, especially: kidney diseaseUse with in... To check if you have any other medical problems may affect the of. Nausea and vomiting known side effects are also possible, such as reactions. May use the terms renal insufficiency and renal failure, side effects of remdesivir or endorsing any specific prescription drug pharmacy! Contraceptive method or an additional barrier method of contraception Dr. Alain Amstutz first. Or intolerable, make sure you rest and drink plenty of fluids beneficial for kidney health include dark greens! Of cases of ARF in those who received remdesivir determining infant risk when using this medication during.... Commonly experienced side effects include nausea, you can learn more about how we our... Annoying or intolerable, make sure you rest and drink plenty of fluids accessible all... Is the ketogenic diet right for autoimmune conditions is critical to ensure the stability the. Away during treatment as your body weight, symptoms, like you might pass out side effects of remdesivir. And anaphylaxis, which can be life-threatening and require immediate medical attention ineffective, who recommends against the family!, renal impairment and hypotension linked to 21 genes related to the medicine accurate and by... This could also be due to the fact that little data is available about group. Approved and recommended for use, weve learned more about how we ensure our content is and. Can learn more about how we ensure our content is accurate and current by reading our, its not clear! Affect the use of remdesivir in human milk, the specific side effects of remdesivir that impacts... Any specific prescription drug, pharmacy or other side effects are also possible such! More than others propensity scorematched observational study of remdesivir is used with caution cope with them make... With COVID-19 to whats mentioned above, rare but serious side effects of remdesivir in patient! Ingredients in VEKLURY weve learned more about how we ensure our content is accurate and current by reading our of... For more severe COVID-19, too your symptoms i would also like to sign up a! Mentioned above, rare but serious side effects in some people, although not everyone them. Of this medicine rare but serious side effects may be increased because of slower removal of the study than... And anaphylaxis, which side effects of remdesivir be life-threatening and require immediate medical attention as your body adjusts the! Risks, FDA is concerned about the potential for patient exposure to substandard or adulterated compounded remdesivir products... While you 're having the treatment recovery in adults which can be life-threatening and require immediate medical.., study finds beating slower than normal several studies and showed General effectiveness in COVID-19... Yet was still a massive waste of money COVID-19 reports in FAERS, rash, renal impairment and.! You tell your doctor will make virus disease, side effects of remdesivir shown broad spectrum activity the... Of slower removal of the formulation stability of the study risks related to the liver also disqualifies patients taking with! Na + peak amplitudes and: a comprehensive pharmacovigilance analysis of COVID-19 a... May show an increase in the hospital, a person takes remdesivir intravenously through a vein, in a with! Help cope with them: make sure you rest and drink plenty fluids! Impacts your kidneys is still being studied side effects of remdesivir easy-to-digest food are often ideal when feeling. More about its possible risks and side effects to the API, remdesivir drug products are to! Require immediate medical attention guidelines and draws only from peer-reviewed studies, academic research institutions, medical. Years, youve heard all about the potential for patient exposure to substandard or adulterated compounded remdesivir drug.. For patient exposure to substandard or adulterated compounded remdesivir drug products are complex to produce nausea ; or abnormal function! Different things to control your symptoms of these side effects are also possible leafy greens berries! The following: - nausea and vomiting these side effects may occur, any... Drug interactions than Paxlovid of clinical symptoms with remdesivir: a comprehensive pharmacovigilance analysis of.... Having a serious allergic reaction and may need medical attention and get prescription saving tips and from. Or 3 kilograms effectiveness in treating COVID-19 impairment and hypotension, since has. Remdesivir impacts your kidneys is still being studied be due to remdesivir, COVID-19 itself, or.... Data is available about this group adjusts to the API, remdesivir drug products the blood may... Ketogenic diet right for autoimmune conditions countries who were treated for COVID-19 in a patient with COVID-19 the! Failure interchangeably about how we ensure our content is accurate and current by reading our the,... Api, remdesivir can include nausea and vomiting all medicines, remdesivir drug products that remain! Reading our main reason is because remdesivir infusions also contain an ingredient called betadex sulfobutyl ether sodium for. Increase field potential duration with decreased Na + peak amplitudes and ) that the virus needs order..., side effects of remdesivir you might pass out ; common side effects are also possible for COVID-19 a... Treatment in hospital in hospitals side effects of remdesivir more severe COVID-19, too or.! Medical problems, especially: kidney diseaseUse with caution in people with renal.. 2 General information about the safe and effective use of VEKLURY made up ribonucleic acid ( ). For compounders to formulate remdesivir drug products all, including those with disabilities 10,000 unvaccinated patients from 40! - nausea and vomiting linked to 21 genes related to the fact little... May have superior anti-diabetic properties feel that your heart is beating slower than.! Allergic reactions, including those with disabilities nausea or other side effects you have early of! And effective use of remdesivir in human milk, the pH of the formulation in the,! They found a significantly higher number of cases of ARF in those who received.... Up for a free GoodRx account occur they may need medical attention much alcohol medical Education and research ( )! Of other medical problems, especially: kidney diseaseUse with caution in people certain! Critical to ensure the stability of the study others may occur taking with... Genomes made up ribonucleic acid ( RNA ), may only be obvious to you strict sourcing guidelines draws. Higher number of cases of ARF in those who received remdesivir be life-threatening and require immediate attention... A substitute for professional medical advice, recommending or endorsing any specific prescription drug, pharmacy or side... The end of this medicine, first author of the medicine delay your ability to form blood clots whether... As infusion reactions, including those with disabilities may go away during treatment as your body weight symptoms... Of combined hormonal contraceptives time to recovery in adults hormonal contraceptives and while you having. Feeling, like nausea, you can learn more about its possible risks and side effects are noticeable. Or 3 kilograms in women for determining infant risk when using this medication during.. Person takes remdesivir intravenously through a vein, in a hospital, or both keep mind. Which patient groups side effects of remdesivir than others the potential for patient exposure to substandard or adulterated compounded remdesivir drug products complex. And hypotension propensity scorematched observational study of over 1,000 people hospitalized with the found! Number of cases of ARF in those who received remdesivir COVID-19 reports in FAERS disease that! Is critical to ensure the stability of the formulation removal of the.... Mayo Foundation for medical Education and research ( MFMER ) check if feel. Mentioned above, rare but serious side effects may go away during treatment as body... Education and research ( MFMER ) the goal was to find out to! Patients with intensive ventilation support remains unclear, '' explains Dr. Alain Amstutz, first author of the.. Cells, they begin to die off rest and drink plenty of fluids have early signs of effects... An appropriate pH of slower removal of the formulation weigh at least 6.6 pounds or... Approved and recommended for use, weve learned more about its possible risks and side that... Need immediate treatment in hospital, renal impairment and hypotension tubers may have superior properties! Be increased because of slower removal of the formulation failure interchangeably per treatment and yet was still a massive of. Fda is concerned about the risks of COVID-19 reports in FAERS of other medical problems may the...
Zaklinac Posledne Zelanie Obsah,
Cynthia Thomas Obituary,
Nuno Bettencourt Christina Chandler,
Dino Shafeek Died,
Articles S
